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In children only the genotype was associated with spina
2020-03-20

In children, only the 6/7 genotype was associated with spina bifida, increasing the risk about 4 times relative to the DHFR 3/3 and 6/6 genotypes. However, the 95%CIs are broad and only few spina bifida patients have the DHFR 6/7 genotype. The effect of the 6/7 genotype on spina bifida risk is there
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A number of studies have been carried out to understand
2020-03-20

A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key Amikacin of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidopsis thaliana
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br Acknowledgements br Introduction Lung cancer treatment
2020-03-20

Acknowledgements Introduction Lung cancer treatment strategies, especially molecular targeted therapy, have progressed rapidly. However, most established treatments are for adenocarcinoma of the lung, not for squamous cell carcinoma (SQCC). SQCC constitutes approximately 30% of lung cancers, w
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br Results and discussion br Conclusions An optimization
2020-03-20

Results and discussion Conclusions An optimization study of the dipeptidyl enoates was performed by chemical structure modifications (Fig. 5). Compound FGA50 displaying R configuration at C-3 was more active than its epimer FGA40. Two modifications of the chemical structure of FGA50 were done:
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In the intestine absorbed cholesterol can
2020-03-20

In the intestine, absorbed cholesterol can either be esterified by ACAT2 (Soat2) and packed into chylomicrons, transported back to the intestinal lumen by ABCG5/ABCG8, or it can be transported into HDL by ABCA1. ACAT2 is confined to enterocytes and hepatocytes and esterifies cholesterol for intracel
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Many countries in all over the world
2020-03-20

Many countries in all over the world generate a large amount of RHA from uncontrolled and controlled burning. RHA is a pozzolanic material due to this high percentage of SiO2 in RHA. Rice husk ash, as a mineral additive, is produced by burning rice husks, which are obtained in the rice milling indus
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Finally naringin and hesperidin have different glycosidic mo
2020-03-20

Finally, naringin and hesperidin have different glycosidic moieties (neohesperidose α-1,2 and rutinose α-1,6 respectively), bound in the same C7 position on the A ring of the flavonoid. The higher value of k/KM of RHA-Phis towards the former substrate suggests that the enzyme shows a preferential hy
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br Methods br Results br Discussion Skin biopsy and microneu
2020-03-18

Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific droperidol organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Lig
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Does a universal mechanism for TLS exist Our
2020-03-18

Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA
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KSTDs are generally reported to
2020-03-18

— Δ1-KSTDs are generally reported to be intracellular enzymes, either soluble or bound to subcellular particles. For instance, the enzymes from C. testosteroni ATCC 11996 and ATCC 17410 [50,90,99], R. equi [29], and N. simplex ATCC 6946 [52] were particulate-bound. On the other hand, the Δ1-KSTDs f
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butein The mitogen activated protein kinase MAPK pathway is
2020-03-18

The mitogen-activated protein kinase (MAPK) pathway is a highly conserved module that mediates the transduction of signals from the cell surface to the nucleus (M. Köbel et al., 2005), meanwhile, it is known to be activated by a wide array of signals ranging from growth and differentiation factors t
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ATP binding cassette transporters such as
2020-03-18

ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from urokinase to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X receptor/re
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MSCs are self renewing multipotent progenitor cells with
2020-03-18

MSCs are self-renewing, multipotent progenitor cells, with multilineage potential to differentiate into adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation, supporting hematopoiesis and homeostatic maintenance. Given their unique therapeutic properties, M
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EMD638683 The reaction of chitosan with DVS should take plac
2020-03-18

The reaction of chitosan with DVS should take place primarily through a nucleophilic attack of the vinyl sulfone groups to the amino groups in chitosan [39,50], although its hydroxyl groups can also be involved, as it happens when using agarose [35]. These reactions create very stable secondary amin
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78 2 The DDRs have also been shown
2020-03-18

The DDRs have also been shown to be regulators of certain immunological functions. DDR1 is expressed in stimulated peripheral blood mononuclear 78 2 (Kamohara et al., 2001) and on activated T cells (Chetoui et al., 2011, Hachehouche et al., 2010, Kamohara et al., 2001). DDR1 can mediate cell migrati
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