• Regulation of pancreatic and cell mass has

  2022-01-29

  

  Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st

• br Materials and methods br Results and discussion

  2022-01-29

  

  Materials and methods Results and discussion Conclusion Altogether, our data provide an unexpected insight into Cx26 trafficking pathway and gap junction assembly in the cochlea. Since many of the disease-causing mutations in GJB2 impair the trafficking and delivery of Cx26 to the cell surf

• To date three GAL subtype receptors have been

  2022-01-29

  

  To date, three GAL subtype receptors have been cloned and characterized, GALR1, GALR2 and GALR3. However, it is unknown which one(s) of the three subtype receptors in bx795 is most effective to regulate insulin resistance in diabetic rats as yet. Recent studies fromanimalmodels of diabetes and obes

• br Medium to long chain fatty

  2022-01-28

  

  Medium- to long-chain fatty acids Medium- to long-chain fatty acids impart a wide range of physiological effects. Medium-chain and long-chain fatty acids have 6–12 carbons and >12 carbons, respectively. As the energy source, these fatty acids are supplied primarily by food intake, biosynthesis, a

• Despite the importance of intratumor phenotypic

  2022-01-28

  

  Despite the importance of intratumor phenotypic heterogeneity for tumor progression and therapy resistance (Marusyk et al., 2012, Marusyk and Polyak, 2010), our understanding of regulators of this process and our ability to modulate them are very limited. Recent advances in genomic sequencing and si

• The electroconductive or electrocatalytic properties of

  2022-01-28

  

  The electroconductive or electrocatalytic properties of conductive moieties including polymers in combination with carbon or metal-based nanomaterials have also been explored. For example, Dong et al. (2017) developed a portable electrochemical immunosensor by creating a film of Prussian blue chitos

• On the other hand the single stranded RNA flavivirus

  2022-01-28

  

  On the other hand, the single-stranded RNA flavivirus hepatitis C virus (HCV), causes type C hepatitis, which often leads to liver cirrhosis, hepatic failure and hepatocellular carcinoma. Its genome of about 9.6kb encodes the structural proteins C, E1, E2, and the nonstructural proteins NS2, NS3, NS

• CCT245737 It is important to note that the GC C

  2022-01-28

  

  It is important to note that the GC-C expression is retained in colon tumours, and therefore GC-C expression can be used as a marker to diagnose metastatic colon cancer [42]. However, expression of uroguanylin and guanylin is often lost in colorectal cancer progression [43]. Therefore, the anti-prol

• Here we used Drosophila and mouse models to address

  2022-01-28

  

  Here, we used Drosophila and mouse models to address the biological function of RALs in the adult intestine. Our results demonstrate a conserved in vivo role for RALs in ISC function during tissue homeostasis and regeneration. ISCs lacking RALs were at a disadvantage compared to wild-type neighbors.

• br Introduction Initial studies of cancer metabolism

  2022-01-28

  

  Introduction Initial studies of cancer metabolism in the early 1920s showed that the cancer phenotype for glucose metabolism is unique, with increased abilities to take up glucose and produce lactate, even under aerobic conditions [1]. This pathway, called aerobic glycolysis or the Warburg effect

• The ketone body receptor HCA is most

  2022-01-28

  

  The ketone body receptor HCA2 is most likely not active under normal conditions, since local levels and plasma levels of ketone bodies such as β-HB are too low to activate the receptor. However, overnight fasting or prolonged starvation results in plasma levels of the ketone body in the millimolar r

• Thus synthesized thienopyrimidine derivatives were evaluated

  2022-01-28

  

  Thus synthesized thienopyrimidine derivatives were evaluated in vitro for GPR119 agonistic activity, and the results are summarized in , , . First, we fixed the 4-methylsulfonylphenyl substituent at the R position on the thienopyrimidine ring, and derivatized at the R position. As shown in , and s

• Selection of the month br Fibrosis br Liver

  2022-01-28

  

  Selection of the month Fibrosis Liver protection device Non-alcoholic steatohepatitis Genetic metabolic liver disease Hepatitis C virus (HCV) infection Hepatitis B virus (HBV) infection Cirrhosis Regeneration Introduction Upon catalysis by hepatic and bacterial enzymes, c

• br Introduction The generic antifibrinolytic drug tranexamic

  2022-01-28

  

  Introduction The generic antifibrinolytic drug tranexamic Fer-1 (TXA) inhibits the protein-protein interaction between plasminogen and fibrin [9]. TXA is frequently used to reduce bleeding in various hemorrhagic conditions, such as during surgical procedures in the heart [19]. However, treatment

• By contrast pentameric glycine receptors GlyR in

  2022-01-28

  

  By contrast, pentameric glycine receptors (GlyR) in humans have four functional subunits, α1− α3 and β (Lynch, 2004) whereas the retina of other mammals have an additional α4 subunit (Harvey et al., 2000), and in humans the α4 subunit is considered a pseudogene as it lacks the 4th transmembrane doma

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