• An adequate regenerative outcome depends on the

  2018-10-20

  

  An adequate regenerative outcome depends on the presence of exogenous and/or endogenous stem cells, or on the existence of a pool of constantly cycling parenchymal cells. Replicating myocytes are small in size and mononucleated, suggesting that they might derive from: a) activation and differentiati

• The current study has investigated the cell death pathway s

  2018-10-20

  

  The current study has investigated the cell death pathway(s) utilized by mESCs in response to etoposide (ETO), a topoisomerase II poison that indirectly induces DNA double strand breaks (DSBs) (Baldwin and Osheroff, 2005). The data show that ETO not only induces cell death with hallmarks of both PCD

• GSK-J1 sodium salt cost In this study we have shown that the

  2018-10-20

  

  In this study, we have shown that the human GSK-J1 sodium salt cost can be used to generate stable hPSC lines to report on GFAP-expressing astrocytes. Furthermore, we have shown that purification of fluorescently labeled astrocytes enables enrichment of regionally defined GFAP+ astrocytes. These n

• CBP is implicated in different biological functions

  2018-10-20

  

  CBP is implicated in different biological functions with an essential role in maintaining normal germ cells development. CBP is expressed in primordial germ cells (PGCs) and in ESCs but is highly expressed in PGCs compared with ESCs. Proper levels of CBP have been shown to be important for hematopoi

• There was a decrease of NF B nuclear translocation on

  2018-10-20

  

  There was a decrease of NF-κB nuclear translocation on immunofluorescence of lung tissue at 4h, in hMSC treated pigs versus untreated controls. The number of na ca exchanger with positively staining nuclei for NF-κB was significantly lower in the treatment group compared to controls. This suggests t

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-10-20

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• Here we used iPSCs to generate cardiomyocytes

  2018-10-20

  

  Here, we used iPSCs to generate cardiomyocytes by reprogramming skin fibroblasts from two patients carrying dissimilar LQTS mutations. Associated with LQT2, HERG-A422T produces trafficking-defective HERG K+ farnesoid x receptor (Kv 11.1) that decrease the rapidly activating delayed rectifier curren

• Madecassic acid During the last decade significant progress

  2018-10-20

  

  During the last decade, significant progress has been made in achieving hematopoietic differentiation from hPSCs. Multiple protocols for hematopoietic differentiation have been developed and have made it possible to routinely produce blood Madecassic acid for experimentation. However, generating HS

• Main Text In little more than a decade stem cell

  2018-10-20

  

  Main Text In little more than a decade, stem cell science has moved rapidly from discovery to testing in the clinic. Hundreds of stem cell clinical trials are estimated to be underway for a wide range of conditions (Trounson et al., 2011, 2012). A 2013 Pharmaceutical Research and Manufacturers of A

• Of importance was our finding of changes in other PD

  2018-10-20

  

  Of importance was our finding of changes in other PD-associated genes, including SNCA (Krüger et al., 1998; Polymeropoulos et al., 1997; Singleton et al., 2003; Zarranz et al., 2004). SNCA is a presynaptic protein and function in regulating synaptic vesicle and neurotransmitter release. Aggregates o

• br Methods br Author contribution statement br Competing fin

  2018-10-20

  

  Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20

• As an initial application of

  2018-10-20

  

  As an initial application of our RNA-seq datasets for discovery of regulatory mechanisms in huSCs, we compared transcriptomes of quiescent huSCs to those of activated huSCs to identify loci that were differentially expressed. In quiescent huSCs, we identified 998 highly expressed genes, including 13

• resveratrol Our results and analyses suggest that the disord

  2018-10-20

  

  Our results and analyses suggest that the disorder notably disrupts the topology of the network. In the context of the patients, these alterations could significantly affect the normal operation of the brain. Such an aspect is important in the framework of studies that highlight the relation between

• Myriocin BMSCs are potential stem cells with

  2018-10-20

  

  BMSCs are potential stem Myriocin with the ability to differentiate into osteoblasts or adipocytes depending on the situation (Pittenger et al., 1999). Indeed, several molecules possess a role in regulating the differentiation of BMSCs (D\'Alimonte et al., 2013; Shui et al., 2003; Yang et al., 2012

• HSC functions are severely compromised following acute and c

  2018-10-20

  

  HSC functions are severely compromised following acute and chronic TLR4 activation (Esplin et al., 2011; Rodriguez et al., 2009). We demonstrated that TRIF signaling is a critical mediator of HSC injury, since its deletion fully restores HSC functions following LPS exposure. Transplantation of LPS L

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