• In conclusion the present study provides the comprehensive e

  2018-11-07

  

  In conclusion, the present study provides the comprehensive examination of the beneficial consequences of therapeutic doses of metformin in the PCOS-like rat uterus (Fig. 8). Strategies to treat PCOS-related reproductive disturbances, including long-term treatment with metformin, remain unstandardiz

• Since fluvastatin has a role in the

  2018-11-07

  

  Since fluvastatin has a role in the suppression of lung adenocarcinoma bone metastasis, we subsequently explored the underlying mechanisms. We found that fluvastatin can induce autophagy in both SPC-A-1 and A549 cells. Electron microscope images showed an increased autophagosomes upon fluvastatin st

• To summarize our work highlights the facts that ECs maintain

  2018-11-07

  

  To summarize, our work highlights the facts that ECs maintain HIV-specific memory B cell responses associated to effective antiviral humoral activities and that Env-specific memory B cell responses are positively associated with the neutralization breadth in HLA-B*57+ ECs. We propose that promoting

• br MALDI TOF profiling of

  2018-11-07

  

  MALDI-TOF profiling of whole sperm glutathione peroxidase and sub-cellular fractions All samples were analyzed by a MALDI-TOF mass spectrometer (Waters Corporation, Micromass Ltd., Manchester, UK) operating in positive linear mode as previously described [1]. Spectral profiles were collected in

• br Experimental design materials and methods br Acknowledgem

  2018-11-07

  

  Experimental design, materials and methods Acknowledgements We acknowledge Aveleda S.A. for supplying the wine used in this study and to SAI Lda for providing the activated carbons. We appreciate the financial support provided to the Research Unit in Vila Real (PEst-OE/QUI/UI0616/2014) by Fund

• Current efforts to address these shortcomings of the WBT inc

  2018-11-07

  

  Current efforts to address these shortcomings of the WBT include, (a) testing in 2 modes: (1) with typical cooking pots and (2) with water in contact with 60% of the surface area of the plancha using a shallow pot (named “comalolla”) covering the whole comal surface to better represent the actual pl

• One way in which these models have been refined and

  2018-11-07

  

  One way in which these models have been refined and developed is with the G418 of hormonal factors. For example Crone and Dahl\'s (2012) model suggests that pubertal hormone changes influence the limbic system, which contribute to social and affective changes. These social and affective influences i

• While most investigations on OFC changes in subjects with su

  2018-11-07

  

  While most investigations on OFC changes in subjects with substance misuse have focused on morphometric imaging techniques, a number of studies have also used functional MRI (fMRI) approaches to assess either resting-state or task-dependent activity in adult and adolescent MJ users. For example, fun

• In terms of substance specific mechanisms of action nicotine

  2018-11-07

  

  In terms of substance-specific mechanisms of action, nicotine facilitates dopaminergic neurotransmission within cytochrome p450 inhibitors reward pathways via activating nicotinic actylcholine (nAch) receptors, including those located on nerve terminals in VTA projections to the NAcc (D\'souza and

• Findings are relevant to both intervention targets

  2018-11-07

  

  Findings are relevant to both intervention targets (e.g., personalized medicine) and intervention mechanisms. For example, an emerging literature suggests that targeted interventions remediating attentional vigilance (‘ABM’ procedures) have a broad impact on clinical anxiety symptoms (Hakamata et al

• br Materials and methods br

  2018-11-07

  

  Materials and methods Results Discussion We hypothesize that the relative weakness of the canonical response to the normal and the 60% compression rates is due to habituation to the stimuli across time. This habituation can be quite fast, and may happen already within the first block. While

• Underlying AI relevant aspects of organizational change

  2018-11-06

  

  Underlying AI relevant aspects of organizational change are important in the context of classroom instruction within a course or a program in architecture. Students are given the opportunity to organize themselves in teams, make selections of environments they see relevant to assess, collaborate eff

• French Jesuits published the handbook dated March preface in

  2018-11-06

  

  French Jesuits published the handbook, dated 19 March 1926 (preface), in this context of polarization between two schools, the old one and the new one, within the China mission. The handbook’s preface opens with a statement: “This brochure is not made for cathedral builders. This is not even an essa

• International Consultancy Firms in the domain of

  2018-11-06

  

  International Consultancy Firms in the domain of Urban Planning (ICFUP), which include architecture- and engineering-oriented firms, are the major agents in expanding the channels of cross-border policy transfer (Peck, 2003) and in transferring policies, practices, models, and references that can be

• The statue of the famous emperor Marcus Aurelius was in

  2018-11-06

  

  The statue of the famous emperor Marcus Aurelius was, in fact, the centerpiece of Michelangelo׳s piazza on the Capitolium. In 1538, Pope Paul III moved the statue here from S. Giovanni in Laterano (i.e., the basilica of S. John at the Lateran) where it stood for centuries and was miraculously preser

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