• ICG001 The patient received multiagent chemotherapy using cy

  2019-04-28

  

  The patient received multiagent chemotherapy using cyclophosphamide, daunorubicin, vincristine, predonisolone and l-asparaginase, and high dose MTX/Ara-C, as well as the single-agent administration of nelarabine, hydroxyurea and tyrosine kinase inhibitors (TKIs) (imatinib and dasatinib). The convent

• While immunogenic action of langerhans cells had

  2019-04-26

  

  While immunogenic action of langerhans Senexin A had thoroughly been illustrated, their tolerogenic action is still being in its infancy stage. Ralph. M. Steinman shared the Nobel Prize in 2011 for his work on dendritic cells and their role in immunity. He uncovered the role of dendritic cells in p

• The pathophysiology underlying ONJ is

  2019-04-26

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• An ERP in the ECG has

  2019-04-26

  

  An ERP in the ECG has been shown to be familial [187–189]. ERP and ERS have been associated with variants in 7 genes. Consistent with the findings that IK-ATP activation can generate an ERP in canine ventricular wedge preparations, variants in KCNJ8 and ABCC9, responsible for the pore- forming and A

• The IntellaTip Mifi catheter has

  2019-04-26

  

  The IntellaTip Mifi catheter has been shown to delineate local electograms better in the isthmus than the conventional bipolar electrode during atrial flutter ablation. The signal amplitude in the mini-electrodes has been noted to be higher than that of the conventional bipolar catheter. This has en

• br Case report His physical examination and basic laboratory

  2019-04-26

  

  Case report His physical examination and basic laboratory data were normal. No organic heart disease other than dextrocardia was detected on electrocardiography, chest radiography, and echocardiography (Fig. 1). A head-up tilt test (HUT) was performed according to the ESC/ACC guidelines [7,8]. T

• A type saddle back type or

  2019-04-26

  

  A type 2 (“saddle-back type”) or type 3 ST-segment elevation cannot substitute for a type 1, unless converted to type 1 with fever or sodium drug challenge. A drug challenge–induced type 1 can be used to diagnose BrS only if accompanied by 1 of the criteria specified above. Type 2 is characterized b

• Economic sanctions have exacerbated the brutality of this

  2019-04-25

  

  Economic sanctions have exacerbated the brutality of this conflict many-fold, removing any prospects for peace and reconciliation. We need some reality to gauge their manifold effects before Syria descends into another Iraq, the devastating health consequences of which were well documented. Syria u

• Brugada syndrome BS is a

  2019-04-25

  

  Brugada syndrome (BS) is a hereditary arrhythmogenic disease characterized by a coved- or saddleback-type ST elevation in the right precordial lead on a 12-lead electrocardiogram (ECG) and ventricular fibrillation (VF) occurring mainly at night. During the past 2 decades, since Brugada and Brugada

• br Case report We report on a year old male

  2019-04-25

  

  Case report We report on a 28-year-old male without any past medical history. After a minor work accident (professional mechanic) he noticed significant pain in his left knee. The pain increased over time and a radiograph was taken. It showed minor bone resorption at the neck of the left proximal

• The osteoid and woven bone

  2019-04-25

  

  The osteoid and woven bone can be seen as interconnected trabeculae (thin or broad) or sheets. The bone surrounding the lesion (host bone) is strong and is made of varying mixtures of woven and lamellar bone [36]. The radiologic appearance of cortical osteoid osteoma arising in the shaft of a long b

• Funding secured by Not applicable Data collection Sheldon

  2019-04-25

  

  Funding secured by: Not applicable. Data collection: Sheldon M. Singh, MD, Ramanan Kumareswaran, MD. Conflict of interest Acknowledgments Introduction Early repolarization pattern (ERP) is characterized by an elevation greater than 0.1mV of the junction between the end of the QRS complex

• The investigators suggest use of doxycycline which

  2019-04-25

  

  The investigators suggest use of doxycycline, which is effective for both diseases, as a possible empirical treatment at the primary level of care. Because the consequences of an untreated true case of rickettsiosis or leptospirosis are much greater than are those of unnecessary treatment, Mayxay an

• At baseline the patient exhibited

  2019-04-24

  

  At baseline, the patient exhibited normal A–H (57ms) and H–V (44ms) intervals, with a sinus smad length of 784ms. Both antegrade and retrograde dual atrioventricular (AV) nodal physiologies were assessed by atrial and ventricular extrastimulus (Fig. 2), without inducible AV nodal reentrant tachycar

• The animal model described here is also expected to

  2019-04-24

  

  The animal model described here is also expected to lead us to design mechanism-based therapeutic interventions for bone metastases of NB. In this context, it is notable that the selective COX-2 inhibitor NS-398, which is known to selectively inhibit COX-2 without affecting COX-1 activity [30], inhi

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