• renin inhibitor IC is a rat mAb specifically binding to insu

  2021-11-08

  

  IC2 is a rat mAb specifically binding to insulin granula [127,128]. Although this mAb was discovered 30 years ago, it has only recently been used for β-cell imaging in vivo. Moore et al. used this mAb for β-cell imaging in 2001 [129]. After DTPA conjugation, IC2 was labeled with 111In. Both in vitro

• GLP is known to be expressed in a

  2021-11-08

  

  GLP-1 is known to be expressed in a subset of taste bud cells and has been shown to co-localize with GPR120 in the circumvallate papillae [22]. Local GLP-1 regulates taste preference for sucrose [54]. Analogous to intestinal mediation of GLP-1 by GPR120, Martin et al.[22] report induction of GLP-1 s

• The top concern for the clinical use of CRISPR Cas

  2021-11-08

  

  The top concern for the clinical use of CRISPR-Cas9 technology is safety. Off-target alterations must be avoided to ensure genome integrity and proper cellular function. WGS found no off-target effects among the top 49 predicted off-target sites. WGS did find 4,658 indels and 1,891 SNVs in sgRNA1/2-

• prostanoid receptors Wasting syndrome is a common complicati

  2021-11-08

  

  Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever (Weinroth et al., 1995). Fever is a highly complex process initiated by the action on the prostanoid receptors thermosensitive cells of a number of endogenou

• ICH induced striatal lesion produced a reduction of

  2021-11-08

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino prostaglandin receptor transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following bra

• br Author contribution br Declaration of

  2021-11-08

  

  Author contribution Declaration of interest Acknowledgements This work was supported by National Natural Science Foundation of China (Grants 81473093) and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM1601ZZ-02). Introduction Diabetes represents a majo

• In summary activated A AR exacerbated the

  2021-11-08

  

  In summary, activated A2AR exacerbated the reverse transport function of endothelial EAATs through a direct or indirect pathway depending on PKA and glutamate levels in response to OGD in vitro, but A2AR inhibition quickly restored the normal transport function. Moreover, the key mechanisms by which

• br Materials and methods br Results

  2021-11-08

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast AZ 10417808 sale by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within min

• br Conclusions The results of

  2021-11-08

  

  Conclusions The results of this work showed that β-glucosidase could be efficiently immobilized onto hydroxyapatite nanoparticles in a single adsorption step. The enzyme adsorption was accomplished by coordination bonds between remaining Ca2+ sites of HA and COO− of amino acids. The immobilizatio

• Introduction Human pathogenic Leishmania protozoa comprise d

  2021-11-08

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• L-690,330 br Conflict of interest statement br Acknowledgeme

  2021-11-08

  

  Conflict of interest statement Acknowledgements This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants [1061044], [1065410] and [1126857], and NHMRC program grant [1055134]); P.M.S. and A.C. are NHMRC Principal and Senior Principal Rese

• br Declaration of competing interests

  2021-11-08

  

  Declaration of competing interests Acknowledgements The authors wish to thank the Natural Science Foundation of Jiangsu Province (BK20171261), the project of outstanding scientific and technological innovation group of Jiangsu Province, the National Science Fund for Distinguished Young Scholar

• br Acknowledgement This work was

  2021-11-08

  

  Acknowledgement This work was supported by National Science Foundation (21475047, 21705051, 21874048), the Science and Technology Planning Project of Guangdong Province (2016B030303010), the Program for the Top Young Innovative Talents of Guangdong Province (2016TQ03N305) and the Foundation for H

• DAMPs are endogenous danger signals that can initiate and pe

  2021-11-08

  

  DAMPs are endogenous danger signals that can initiate and perpetuate a noninfectious qx 314 during cell death [23]. HMGB1 is a well-studied nuclear DAMP in various types of regulated necrosis and has been implicated in the pathogenesis of infection and sterile inflammation. Our current data indicate

• In the FARM motifs of GGPPSs hydrophobic

  2021-11-08

  

  In the FARM motifs of GGPPSs, hydrophobic Cyclopiazonic acid are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP syntha

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