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A correlation analysis was performed to
2024-04-18
A correlation analysis was performed to investigate a possible relationship between serum resistin levels and MG-ADL. We observed a significant relationship between serum resistin levels and MG-ADL scores in AChR-GMG-positive cases (r=0.285, p=0.032; Fig. 1C). There were also significant correlation
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br Dihydrotestosterone in adult fish and frogs
2024-04-18
Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance
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br Conclusion br List of abbreviations br Acknowledgment
2024-04-18
Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S
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br Introduction Human esophageal carcinoma is one
2024-04-18
Introduction Human esophageal carcinoma is one of the most frequently diagnosed cancers, ranked as the eighth leading causes of cancer-related mortality worldwide. Esophagus squamous cell carcinoma (ESCC) is the most common histological type of esophageal carcinomas, especially with a higher inci
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To maintain ATP levels postmortem muscle mobilizes
2024-04-18
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield Myriocin australia 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (Pinitiation of the experiment. We expected that if myosin ATPase is li
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We also show that in both ATM
2024-04-17
We also show that in both ATM proficient and deficient/mutant 10-Hydroxycamptothecin australia the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHE
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Bleomycin A5 hydrochloride Further important evidence for G
2024-04-17
Further important evidence for G protein signaling on early endosomes has been subsequently obtained for the β2-adrenegic receptor using fluorescently-tagged conformation-sensitive nanobodies selectively recognizing the active receptor and Gs protein [43]. More recently, our group used a combinatio
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Bioavailability has been defined as the amount
2024-04-17
Bioavailability has been defined as the amount of a drug given by any route, other than intravenously, that reaches general circulation and is available at the site of action [86]. The low bioavailability observed with the initial intravaginal devices (16%) was attributed to the melting point of the
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br Apelin The APJ receptor ligand apelin
2024-04-17
Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino AMG-517 sale residues that are cleaved into biologically active C-terminal fragments of various
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What are the in situ effects
2024-04-17
What are the in-situ effects of multi-site CaM associations with AT1R? Kai et al. showed that synthetic peptides corresponding to residues 125–137 (rat sequence) in SMD2, 217–227 in the N-terminal side of SMD3, and 304–316 in SMD4JM inhibit to various degrees AngII-induced GTPase activity of isolate
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Immunohistochemistry in tissue samples showed the expression
2024-04-17
Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of Zacopride hydrochloride receptor tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-activa
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Our observation that squalestatin caused only small differen
2024-04-17
Our observation that squalestatin caused only small differences in the production of Aβ40 and Aβ42 was in contrast to prior reports of the effects of other cholesterol synthesis inhibitors. This may be due to using squalestatin, a more specific cholesterol synthesis inhibitor that does not affect is
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Our previous study showed that TRIM could target TSC TSC
2024-04-17
Our previous study showed that TRIM31 could target TSC1-TSC2 complex and contributed to the clinical cancer progression [6]. In this study, we showed that TRIM31 could directly target p53 for ubiquitous degradation and further mediated anoikis-resistance of HCC cells. To further clarify the role of
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and LO are members of the
2024-04-17
5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic Phosphatase Inhibitor Cocktail 1 (100X in DMSO) into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo stud
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Various compounds have been designed
2024-04-17
Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic Sorafenib moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a pot
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