• Discovery of longevity genes such as SirT gene

  2018-10-22

  

  Discovery of longevity genes such as SirT gene family has resulted in tremendous enthusiasm among many scientists. Numerous studies have shown that this gene family uses intermediate metabolites such as acetyl-CoA, ATP, and NAD+ or nucleosomes to modify and control the activity and expression of pat

• Elevated XO activity enhances lipid

  2018-10-22

  

  Elevated XO activity enhances lipid peroxidation due to the attendant excessive generation of reactive oxygen species (ROS), decreases in the levels of non-protein antioxidants including reduced glutathione (GSH), vitamin C and vitamin E; and the inflammation associated with neutrophil infiltration

• Our xeno free culture conditions made single cell

  2018-10-22

  

  Our xeno-free culture conditions made single cell passaging possible, and we could also generate EBs from single cell suspensions. Although both hESC lines retained a normal karyotype, we did observe an accumulation of a chromosomal abnormality in one of our cultures. After 13 passages under xeno-fr

• The interaction between intact AM and limbal explants does n

  2018-10-22

  

  The interaction between intact AM and limbal explants does not only degrade the matrix of the AM but also activate intracellular signaling cascades triggered by matrix components. By use of selective pharmacological inhibitors, we investigated the downstream effectors critical for intact AM-induced

• br Limitations Adenoviral infection was performed

  2018-10-22

  

  Limitations Adenoviral infection was performed 7days before FACS analysis. Due to constraints inherent in the hiPSC-CM differentiation system, the efficiency of adenoviral infection was not 100%. The percentages of the specific sub-populations reported do not take into account false negatives and

• Surgical transplantation Algvere et al or translocation van

  2018-10-22

  

  Surgical transplantation (Algvere et al., 1997) or translocation (van Meurs and Van Den Biesen, 2003) of RPE sheets into the macula preserves central vision, providing proof of concept that RPE transplantation can be beneficial in AMD (reviewed in Binder et al., 2007). Stem cell technology now provi

• A whole genome transcriptome analysis

  2018-10-22

  

  A whole genome transcriptome analysis was carried out to clarify the mechanisms of the cell type specific cytotoxicity of HDAC inhibition on the abnormal cells. The transcriptome analysis revealed the HDAC inhibitor responsive genes in the normal and abnormal cells. The genes with altered levels in

• An adequate regenerative outcome depends on the

  2018-10-20

  

  An adequate regenerative outcome depends on the presence of exogenous and/or endogenous stem cells, or on the existence of a pool of constantly cycling parenchymal cells. Replicating myocytes are small in size and mononucleated, suggesting that they might derive from: a) activation and differentiati

• The current study has investigated the cell death pathway s

  2018-10-20

  

  The current study has investigated the cell death pathway(s) utilized by mESCs in response to etoposide (ETO), a topoisomerase II poison that indirectly induces DNA double strand breaks (DSBs) (Baldwin and Osheroff, 2005). The data show that ETO not only induces cell death with hallmarks of both PCD

• GSK-J1 sodium salt cost In this study we have shown that the

  2018-10-20

  

  In this study, we have shown that the human GSK-J1 sodium salt cost can be used to generate stable hPSC lines to report on GFAP-expressing astrocytes. Furthermore, we have shown that purification of fluorescently labeled astrocytes enables enrichment of regionally defined GFAP+ astrocytes. These n

• CBP is implicated in different biological functions

  2018-10-20

  

  CBP is implicated in different biological functions with an essential role in maintaining normal germ cells development. CBP is expressed in primordial germ cells (PGCs) and in ESCs but is highly expressed in PGCs compared with ESCs. Proper levels of CBP have been shown to be important for hematopoi

• There was a decrease of NF B nuclear translocation on

  2018-10-20

  

  There was a decrease of NF-κB nuclear translocation on immunofluorescence of lung tissue at 4h, in hMSC treated pigs versus untreated controls. The number of na ca exchanger with positively staining nuclei for NF-κB was significantly lower in the treatment group compared to controls. This suggests t

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-10-20

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• Here we used iPSCs to generate cardiomyocytes

  2018-10-20

  

  Here, we used iPSCs to generate cardiomyocytes by reprogramming skin fibroblasts from two patients carrying dissimilar LQTS mutations. Associated with LQT2, HERG-A422T produces trafficking-defective HERG K+ farnesoid x receptor (Kv 11.1) that decrease the rapidly activating delayed rectifier curren

• Madecassic acid During the last decade significant progress

  2018-10-20

  

  During the last decade, significant progress has been made in achieving hematopoietic differentiation from hPSCs. Multiple protocols for hematopoietic differentiation have been developed and have made it possible to routinely produce blood Madecassic acid for experimentation. However, generating HS

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