• br Acknowledgments We thank Richard A Flavell Yale Universit

  2018-10-23

  

  Acknowledgments We thank Richard A. Flavell, Yale University, and Roger J. Davis, University of Massachusetts Medical School, for their kind gift of the MKK3-deficient mice. We also thank Mary LoPresti and Jean Kanyo (Yale MS & Proteomics Resource) for their assistance with sample preparation and

• br Experimental methods br Results

  2018-10-22

  

  Experimental methods Results and discussion Conclusions Acknowledgments This work was sponsored by the Centre for Industrial Photonics, Institute for Manufacture, Department of Engineering, University of Cambridge; the Natural Science Foundation of China (51271170); China International S

• br Materials and methods High nitrogen austenitic

  2018-10-22

  

  Materials and methods High nitrogen austenitic stainless steel (HNS) plates in cold worked condition are used in the present study. Schematic diagram of joint geometry and plate dimensions are given in Fig. 1. A set of plates with single-V butt joint welded using shielded metal arc welding (SMAW)

• Clinically sigmoid volvulus and intussusception in children

  2018-10-22

  

  Clinically sigmoid volvulus and intussusception in children are difficult to distinguish, although children with intussusception are usually younger than those with sigmoid volvulus. The most common clinical picture consists of cramping abdominal pain and abdominal distention. In 1985, McCalla et al

• br Results The ligation and nonligation groups were well

  2018-10-22

  

  Results The ligation and nonligation groups were well matched for sizes of internal ring orifices (p = 0.707; Table 1) and incidence of coexisting Pantaloon hernia (p = 0.826). The range of operation times was 65–146 minutes in the ligation group and 72–164 minutes in the nonligation group. The a

• In most of the cases the preoperative diagnosis

  2018-10-22

  

  In most of the cases, the preoperative diagnosis of gastric teratoma is difficult. Plain films usually reveal a soft tissue mass with associated irregular areas of calcifications. The presence of irregular areas of calcification on abdominal radiographs or on abdominal CT may give some clues to the

• br Materials and methods br Results and

  2018-10-22

  

  Materials and methods Results and discussion Conclusion In summary, some members of the fecal bacteria utilized garlic fructans to grow resulting in a decrease in the pH of the cultures in vitro. Bifidobacteria were stimulated while Clostridia were inhibited by the garlic fructans. Essentia

• Calculated daily intake of fluoride from water green leafy v

  2018-10-22

  

  Calculated daily intake of fluoride from water, green leafy vegetables, food grains, cow milk and cooked rice in high fluorotic areas of the study shows 3–5 times higher fluoride than 2mg/d that was estimated as worldwide average for fluoride intake in children and adolescent. For children and adole

• Discovery of longevity genes such as SirT gene

  2018-10-22

  

  Discovery of longevity genes such as SirT gene family has resulted in tremendous enthusiasm among many scientists. Numerous studies have shown that this gene family uses intermediate metabolites such as acetyl-CoA, ATP, and NAD+ or nucleosomes to modify and control the activity and expression of pat

• Elevated XO activity enhances lipid

  2018-10-22

  

  Elevated XO activity enhances lipid peroxidation due to the attendant excessive generation of reactive oxygen species (ROS), decreases in the levels of non-protein antioxidants including reduced glutathione (GSH), vitamin C and vitamin E; and the inflammation associated with neutrophil infiltration

• Our xeno free culture conditions made single cell

  2018-10-22

  

  Our xeno-free culture conditions made single cell passaging possible, and we could also generate EBs from single cell suspensions. Although both hESC lines retained a normal karyotype, we did observe an accumulation of a chromosomal abnormality in one of our cultures. After 13 passages under xeno-fr

• The interaction between intact AM and limbal explants does n

  2018-10-22

  

  The interaction between intact AM and limbal explants does not only degrade the matrix of the AM but also activate intracellular signaling cascades triggered by matrix components. By use of selective pharmacological inhibitors, we investigated the downstream effectors critical for intact AM-induced

• br Limitations Adenoviral infection was performed

  2018-10-22

  

  Limitations Adenoviral infection was performed 7days before FACS analysis. Due to constraints inherent in the hiPSC-CM differentiation system, the efficiency of adenoviral infection was not 100%. The percentages of the specific sub-populations reported do not take into account false negatives and

• Surgical transplantation Algvere et al or translocation van

  2018-10-22

  

  Surgical transplantation (Algvere et al., 1997) or translocation (van Meurs and Van Den Biesen, 2003) of RPE sheets into the macula preserves central vision, providing proof of concept that RPE transplantation can be beneficial in AMD (reviewed in Binder et al., 2007). Stem cell technology now provi

• A whole genome transcriptome analysis

  2018-10-22

  

  A whole genome transcriptome analysis was carried out to clarify the mechanisms of the cell type specific cytotoxicity of HDAC inhibition on the abnormal cells. The transcriptome analysis revealed the HDAC inhibitor responsive genes in the normal and abnormal cells. The genes with altered levels in

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